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Reference Grieve and colleagues, 200512 Study characteristics Research question What are the stated objectives of the evaluation? To assess whether antiviral therapy either IFN or PEG combined with RBV ; is cost-effective at a mild stage compared with waiting and only treating those cases who progress to moderate disease. Study population What definition was used for mild chronic hepatitis C? Patients with mild chronic hepatitis C. What are the characteristics of the baseline cohort for the evaluation? 40 years Age Sex 60% male Race if appropriate ; Genotype 50% genotype 1 Other characteristics Interventions and comparators What number of interventions strategies were included? Four interventions were included. Was a no treatment supportive care strategy included? A no treatment strategy was included. Describe interventions strategies. Intervention strategy 1: mild disease, no treatment; moderate disease, IFN 2b + RBV. Intervention strategy 2: mild disease, IFN 2b + RBV; moderate disease, no treatment. Intervention strategy 3: mild disease, no treatment; moderate disease, PEG 2b + RBV. Intervention strategy 4: mild disease, PEG 2b + RBV; moderate disease, no treatment, Analytical perspective What is the perspective adopted for the evaluation health service, health and personal social services, third-party payer, societal, i.e. including costs borne by individuals and lost productivity ; ? A health service perspective was taken to costing; the inpatient and outpatient costs incurred from hospital care were included. Study type Cost-effectiveness costutility costbenefit analysis? Cost-effectiveness study.
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We have long term research undertakings totaling CHF 4 million in the aggregate as of December 31, 2002. We intend to fund these expenditures from internally generated resources. Regulation Foodstuffs are highly regulated in order to protect the public health. The following areas are generally subject to international and national food regulations: development, manufacturing, packaging, quality food standards, ingredients ; , safety, labeling and advertising of foods. In the US, Medical Nutrition's products are covered by FDA regulations covering medical foods, dietary supplements under the DSHEA regulations ; and medical devices. Intellectual Property Our Medical Nutrition businesses are brand-oriented and, therefore, we consider our trademarks to be of utmost value. Trademarks protect most of our brands in the majority of the markets where these brands are sold, and we vigorously protect these trademarks from infringement. Our most important trademarks are used in a number of countries. Local variations of these international trademarks are employed where legal or linguistic considerations require the use of an alternative. Wherever possible our products are protected by patents. Among other things, patents may cover the products themselves, including the product's active substance and its formulation. Patents may also cover the processes for manufacturing a product, including processes for manufacturing intermediate substances used in the manufacture of the products. Patents may also cover particular uses of a product, such as its use to treat a particular disease, or its dosage regimen. It is our policy to seek the broadest possible protection for significant product developments in all major markets. INFANT & BABY In 2002, our Infant & Baby Business Unit, best known for its Gerber products, posted CHF 2.1 billion in sales, which amounted to a 3% increase in local currencies over 2001, and represented 6% of the Group's sales. The major contributor to this continued solid performance is the US, spurred by innovations in the Juice, Graduates and Tender Harvest lines. An outstanding success has been Lil' Entrees, a new line of microwavable convenience meals in trays. These results are especially strong, given that 2002 baby products industry sales have been negatively impacted by a 1% decline in births in the US in 2001. Besides nutrition products, the company offers a wide variety of other products for infants and toddlers, including a baby accessory line featuring nursing and feeding aids ; , wellness products such as lotions and washes ; , and life insurance. As of December 31, 2002, our Infant & Baby Business Unit employed 4, 901 associates worldwide and calan. 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